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leukocyte immunoglobulin-like receptor subfamily B member 5; leukocyte immunoglobulin-like receptor 8; LIR-8; CD85 antigen-like family member C; CD85c (LILRB5, LIR8)
Function:
- may act as receptor for class 1 MHC antigens
Structure:
- contains 2 ITIM motifs
- phosphorylated ITIM motif can bind the SH2 domain of several SH2 domain-containing phosphatases
- contains 4 Ig-like C2-type domains (immunoglobulin-like)
Compartment:
- membrane; single-pass type 1 membrane protein
Alternative splicing: named isoforms=3
Expression: detected in a natural killer (NK) cells
Pathology:
- variant rs12975366: T > C Asp247Gly associated with lower serum creatine kinase & serum lactate dehydrogenase & with statin myopathy [2]
General
CD85 or leukocyte immunoglobulin-like receptor family protein
Properties
SIZE: entity length = 590 aa
MW = 64 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-23}
immunoglobulin superfamily domain {27-116}
MOTIF: cysteine residue {C49}
MODIFICATION: cysteine residue {C98}
cysteine residue {C98}
MODIFICATION: cysteine residue {C49}
immunoglobulin superfamily domain {111-228}
MOTIF: N-glycosylation site {N139}
cysteine residue {C144}
MODIFICATION: cysteine residue {C195}
cysteine residue {C195}
MODIFICATION: cysteine residue {C144}
immunoglobulin superfamily domain {224-313}
MOTIF: cysteine residue {C244}
MODIFICATION: cysteine residue {C295}
N-glycosylation site {N279}
cysteine residue {C295}
MODIFICATION: cysteine residue {C244}
immunoglobulin superfamily domain {337-418}
MOTIF: N-glycosylation site {N339}
cysteine residue {C344}
MODIFICATION: cysteine residue {C395}
cysteine residue {C395}
MODIFICATION: cysteine residue {C344}
transmembrane domain {459-479}
immunoreceptor tyrosine-based inhibitory motif (ITIM) {552-557}
immunoreceptor tyrosine-based inhibitory motif (ITIM) {582-587}
Database Correlations
OMIM 604814
UniProt O75023
Entrez Gene 10990
Kegg hsa:10990
References
- UniProt :accession O75023
- Siddiqui MK, Maroteau C, Veluchamy A et al
A Common Missense Variant of LILRB5 Is Associated With Statin
Intolerance and Myalgia.
Eur Heart J. 2017;38(48):3569-3575
Medscape. March 2018
PMID: 29020356 Free PMC Article
https://www.medscape.com/viewarticle/891063