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Lifestyle for Brain Health index (LIBRA)
Procedure:
LIBRA index includes
- modifiable dementia risk factors
- physical inactivity
- smoking
- obesity
- depression
- diabetes mellitus type 2
- chronic hypertension
- hypercholesterolemia
- chronic heart disease
- chronic kidney disease
- protective factors
- Mediterranean diet adherence
- low to moderate alcohol use
- a 30 minute neuropsychological battery to measure cognitive performance,
- memory
- information processing
- executive function
- attention
Clinical significance:
- higher LIBRA scores correlate with higher dementia risk
Radiology:
- brain MRI outcomes include
- decreased gray matter volume*
- white matter volume
- increased CSF volume*
- white matter hyperintensities*
* associated with higher LIBRA scores
Notes:
- men had higher LIBRA scores than women
General
index
References
- Heger IS, Deckers K, Schram MT et al.
Associations of the Lifestyle for Brain Health Index with structural
brain changes and cognition: Results from The Maastricht Study.
Neurology 2021 Sep 28; 97:e1300.
PMID: 34433680 PMCID: PMC8480401 Free PMC article
https://n.neurology.org/content/97/13/e1300