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LIM/homeobox protein LHX1; LIM homeobox protein 1; homeobox protein Lim-1; hLim-1 (LHX1, LIM1)
Function:
- transcription factor (putative)
- may play a role in early mesoderm formation & later in lateral mesoderm differentiation & neurogenesis
- interacts with LDB1 via the tandem LIM domains
Structure:
- the LIM domains exert a negative regulatory function; disruption of the LIM domains produces an activated form
- 2 activation domains & a negative regulatory domain exist C-terminal to the homeobox (putative)
- contains 1 homeobox DNA-binding domain
- contains 2 LIM Zn+2-binding domains
Compartment: nucleus (probable)
Expression:
- expressed in brain, thymus, & tonsils
Pathology:
- expressed in leukocytes in chronic myeloid leukemia
- expressed in 58% of acute myeloid leukemia (AML) cell lines
General
LIM/homeodomain protein
Properties
SIZE: MW = 44 kD
entity length = 404 aa
COMPARTMENT: cell nucleus
MOTIF: LIM domain {4-54}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
LIM domain {63-117}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
homeodomain
SITE: 180-239
Database Correlations
OMIM 601999
UniProt P48742
PFAM correlations
Kegg hsa:3975
References
UniProt :accession P48742