luteinizing hormone; lutropin (LH)

Function: - carbohydrate sulfotransferase (CHST8, CHST9) required for biosynthesis of luteinizing hormone - secreted in bursts in direct response to each pulse of GnRH from the hypothalamus - binds to LH-receptor on surface of Leydig cells of the testes - evokes secretion of testosterone & estradiol from Leydig cells Pathology: - gene mutations in beta subunit (LH-beta): a) female patients present with amenorrhea b) no androgen precursors are produced by theca cells Pharmacokinetics: - plasma 1/2 life is 20-30 minutes

Related

carbohydrate sulfotransferase 8; galNAc-4-O-sulfotransferase 1; galNAc-4-ST1; galNAc4ST-1; N-acetylgalactosamine-4-O-sulfotransferase 1 (CHST8) gonadotropin-releasing hormone/factor; gonadoliberin; LH/FSH-releasing hormone (GnRH, LHRH) Leydig cell luteinizing hormone (LH) in serum lutropin (LH) Ag in tissue Lutropin-choriogonadotropic hormone receptor; LH/CG-R; LSH-R; Luteinizing hormone receptor; LHR (LHCGR, LCGR, LGR2 LHRHR) menotropins (Pergonal, Repronex) pituitary adenoma/LH secreting

General

multisubunit protein pituitary gonadotropin

Properties

COMPARTMENT: plasma SUBUNITS: glycoprotein hormone alpha chain MOTIF: cysteine residue {C31} MODIFICATION: cysteine residue {C55} cysteine residue {C34} MODIFICATION: cysteine residue {C84} cysteine residue {C52} MODIFICATION: cysteine residue {C106} cysteine residue {C55} MODIFICATION: cysteine residue {C31} cysteine residue {C56} MODIFICATION: cysteine residue {C108} N-glycosylation site {N76} cysteine residue {APP C83 peptide fragment SIZE: entity length = 83 aa} MODIFICATION: cysteine residue {C111} cysteine residue {C84} MODIFICATION: cysteine residue {C34} N-glycosylation site {N102} cysteine residue {C106} MODIFICATION: cysteine residue {C52} cysteine residue {C108} MODIFICATION: cysteine residue {C56} cysteine residue {C111} MODIFICATION: cysteine residue {APP C83 peptide fragment SIZE: entity length = 83 aa} LHB MOTIF: cysteine residue {C29} MODIFICATION: cysteine residue {C77} cysteine residue {C43} MODIFICATION: cysteine residue {C92} cysteine residue {C46} MODIFICATION: cysteine residue {C130} N-glycosylation site {N50} cysteine residue {C54} MODIFICATION: cysteine residue {C108} cysteine residue {C58} MODIFICATION: cysteine residue {C110} cysteine residue {C77} MODIFICATION: cysteine residue {C29} cysteine residue {C92} MODIFICATION: cysteine residue {C43} cysteine residue {C108} MODIFICATION: cysteine residue {C54} cysteine residue {C110} MODIFICATION: cysteine residue {C58} cysteine residue {C113} MODIFICATION: cysteine residue {C120} cysteine residue {C120} MODIFICATION: cysteine residue {C113} cysteine residue {C130} MODIFICATION: cysteine residue {C46} MISC-INFO: 1/2life 20-30 MIN

References

Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998

Component-of

follicle stimulating hormone/luteinizing hormone menotropins (Pergonal, Repronex)

Components

glycoprotein hormone alpha chain luteinizing hormone [LH]-beta chain; lutropin beta chain (LHB)