relaxin receptor 2; leucine-rich repeat-containing G protein-coupled receptor 8; G protein-coupled receptor affecting testicular descent (LGR8, GREAT, RXFP2)

Function: - receptor for relaxin - activity is mediated by Gs proteins leading to stimulation of adenylate cyclase & an increase of cAMP - may also be a receptor for Leydig insulin-like peptide (INSL3) Structure: - belongs to the G-protein coupled receptor 1 family - contains 1 LDL-receptor class A domain - contains 10 LRR repeats (leucine-rich repeats) Compartment: cell membrane Expression: - expressed mainly in the brain, kidney, muscle, testis, thyroid, uterus, peripheral blood cells & bone marrow Pathology: - defects in RXFP2 are a cause of cryptorchidism Note: uncertain whether Met-1 or Met-18 is the initiator

Properties

SIZE: MW = 86 kD entity length = 754 aa COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-416} MOTIF: LDL-receptor class A {44-81} N-glycosylation site {N54} leucine-rich repeat SITE: 136-159 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N138} leucine-rich repeat (5) SITE: 161-279 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N274} leucine-rich repeat (3) SITE: 281-351 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N335} leucine-rich repeat SITE: 352-375 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N378} transmembrane domain {417-437} cytoplasmic loop {438-455} transmembrane domain {456-476} exoplasmic loop {477-507} MOTIF: cysteine residue {C495} MODIFICATION: cysteine residue {C573} transmembrane domain {508-528} cytoplasmic loop {529-537} transmembrane domain {538-558} exoplasmic loop {559-592} MOTIF: cysteine residue {C573} MODIFICATION: cysteine residue {C495} transmembrane domain {593-613} cytoplasmic loop {614-639} transmembrane domain {640-660} exoplasmic loop {661-673} transmembrane domain {674-694} cytoplasmic domain {695-754}

Database Correlations

OMIM correlations MORBIDMAP 606655 UniProt Q8WXD0 PFAM correlations Kegg hsa:1220

References

UniProt :accession Q8WXD0