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galectin-9 (soluble galactoside-binding lectin 9, HOM-HD-21, ecalectin, LGALS9)
Function:
- binds galactosides
- may play a role in thymocyte-epithelial interactions relevant to the biology of the thymus
- short isoform acts as an eosinophil chemoattractant
- ligand for HAVCR2/TIM3
- induces T-helper type 1 lymphocyte (Th1) death
Structure:
- contains two homologous but distinct carbohydrate-binding domains
- contains 2 galectin domains
Compartment:
- cytoplasm (putative)
- secreted, may also be secreted by a non-classical secretory pathway (putative)
Alternative splicing:
- named isoforms=2
- additional isoforms seem to exist
Expression:
- expressed in peripheral blood leukocytes & lymphatic tissues
Pathology: overexpressed in Hodgkin's disease tissue
General
galaptin, galectin, galactoside-binding lectin, lactose-binding lectin or S-lectin
Properties
SIZE: entity length = 355 aa
MW = 40 kD
COMPARTMENT: cytoplasm
MOTIF: Galectin 1 {17-148}
MOTIF: binding site
SITE: 82-88
FOR-BINDING-OF: BETA-GALACTOSIDE
binding site
FOR-BINDING-OF: galactoside
MOTIF: tryptophan residue
Galectin 2 {227-355}
MOTIF: binding site
SITE: 287-293
FOR-BINDING-OF: BETA-GALACTOSIDE
Database Correlations
OMIM 601879
UniProt O00182
Pfam PF00337
Entrez Gene 3965
References
- UniProt :accession O00182
- Entrez Gene :accession 3965