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galectin-3; galactose-specific lectin 3; mac-2 antigen; IgE-binding protein; 35 kD lectin; carbohydrate-binding protein 35; CBP 35; laminin-binding protein; lectin L-29; L-31; galactoside-binding protein; GALBP (LGALS3 MAC2)
Function:
1) galactose-specific lectin which binds IgE
2) in conjunction with alpha-3, beta-1 integrin & CSPG4, may facilitate endothelial cell migration
3) together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (putative)
3) forms a complex with ITGA3, ITGB1 & CSPG4
4) interacts with LGALS3BP, LYPD3, UACA & CYHR1
5) probably forms homodimers or heterodimers
Structure: contains 1 galectin domain
Compartment:
- nucleus
- cytoplasmic in adenomas & carcinomas
- may be secreted by a non-classical secretory pathway & associate with cell surface
Expression:
- expressed in colonic epithelium & activated macrophages
Related
galectin 3 Ag in tissue
galectin-3-binding protein (lectin galactoside-binding soluble 3-binding protein, Mac-2-binding protein, Mac-2 BP, MAC2BP, tumor-associated antigen 90K, LGALS3BP, M2BP)
General
galaptin, galectin, galactoside-binding lectin, lactose-binding lectin or S-lectin
phosphoprotein
Properties
SIZE: entity length = 250 aa
MW = 26 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S6}
Ser phosphorylation site {S12}
8 X 9 AA tandem repeats of Y-P-G-X(3)-P- G-A {36-109}
MOTIF: consensus repeat {36-44}
consensus repeat {45-53}
consensus repeat {54-62}
consensus repeat {63-69}
consensus repeat {70-78}
consensus repeat {79-88}
consensus repeat {89-100}
consensus repeat {101-109}
Galectin {118-248}
MOTIF: cysteine residue {C173}
MODIFICATION: cysteine residue {C-INTERCHAIN}
Beta-galactoside binding {181-187}
Database Correlations
OMIM 153619
UniProt P17931
Pfam PF00337
Entrez Gene 3958
Kegg hsa:3958
References
- Entrez Gene :accession 3958
- UniProt :accession P17931