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galectin-1; lectin galactoside-binding soluble 1; beta-galactoside-binding lectin L-14-I; lactose-binding lectin 1; S-lac lectin 1; galaptin; 14 kD lectin; HPL; HBL; MAPK-activating protein PM12 (LGALS1)
Function:
- may regulate apoptosis, cell proliferation & cell differentiation
- binds beta-galactoside & a wide array of complex carbohydrates
- inhibits CD45 protein phosphatase activity & thus dephosphorylation of Lyn kinase
- binds LGALS3BP
- interacts with CD2, CD3, CD4, CD7, CD43 & CD45
Structure:
- homodimer
- contains 1 galectin domain
Compartment:
- secreted, extracellular space, extracellular matrix
Expression:
- expressed in cardiac muscle, smooth muscle, skeletal muscle, neurons, thymus, kidney, placenta & hematopoietic cells
General
galaptin, galectin, galactoside-binding lectin, lactose-binding lectin or S-lectin
Properties
SIZE: entity length = 135 aa
MW = 15 kD
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Galectin {4-135}
MOTIF: Beta-galactoside binding {45-49}
binding site
SITE: 53-53
FOR-BINDING-OF: Beta-galactoside
binding site
SITE: 62-62
FOR-BINDING-OF: Beta-galactoside
Beta-galactoside binding {69-72}
Database Correlations
OMIM 150570
UniProt P09382
Pfam PF00337
Entrez Gene 3956
Kegg hsa:3956
References
- UniProt :accession P09382
- Entrez Gene :accession 3956
- Functional glycomics gateway - glycan binding Note: galectin-1
http://www.functionalglycomics.org/glycomics/GBPServlet?&operationtype=view&cbpId=cbp_hum_Stlect_00116