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Leydig (hilus) cell tumor
Epidemiology:
- ~ 15% of steroid cell tumors
Pathology:
- ~1-15 cm diameter
- well circumscribed
- often hemorrhagic
Microscopic pathology:
- Reinke's crystalloids
- sheets/cords/nests
- uniform rounded or polyhedral cells
- large central nuclei, prominant nucleolus
- finely granular eosinophilic cytoplasm, may have vacuoles
- fibrinoid degeneration of large blood vessels
Clinical manifestations:
- hirsutism and virilism in ~80%
- occasionally estrogenic manifestations
General
sex cord stromal tumor