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Lewy neurite
Abnormal neurites found in patients with diffuse Lewy body disease & some cases of Parkinson's disease.
Distribution:
1) CA2-CA3 of the hippocampus
2) amygdala, accessory cortical nuclei
3) nucleus basalis of Meynert
4) brainstem of patients with diffuse Lewy body disease
5) olfactory bulb
6) intermediolateral columns of spinal cord
7) sympathetic and parasympathetic ganglia
8) enteric, cardiac, and pelvic neurons
9) adrenal medulla [2]
Components:
components of Lewy neurites include:
1) neurofilaments
2) ubiquitin
3) alpha synuclein
Pathology:
- the mechanism of formation of Lewy neurites & the role of Lewy neurites in the pathogenesis of Lewy body dementia is unknown
- Lewy neurites may contribute to the dementia of Lewy body dementia, but may be found in cases of Parkinson's disease without dementia
Related
alpha-synuclein; non-A beta component of AD amyloid; non-A4 component of amyloid; NACP (SNCA, NACP, PARK1)
Lewy body dementia
neurofilament protein
Parkinson's disease (paralysis agitans, PD)
ubiquitin (UBCEP2, UBB, UBC)
General
abnormal morphologic structure (malformation)
neurite
Properties
CELL: neuron
PATHOLOGY: Lewy body dementia
References
- Hansen L., Dementia with Lewy bodies, In: Alzheimer's Disease,
2nd ed, Terry RD et al ed, Lippincott, Williams & Wilkins,
Philadelphia, 1999
- Jellinger KA. Mov Disord. 2003 Sep;18 Suppl 6:S2-12.
PMID: 14502650