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levosimendan (Simdax)

Contraindications: - of no benefit for sepsis - no benefits for elderly at risk for low cardiac output syndrome following cardiac bypass surgery [3] or cardiac surgery in general [4] * may diminish likelihood of successful weaning from ventilator Dosage: - 0.05 to 0.2 ug/kg/min Mechanism of action: - inotrope & calcium-sensitizing drug - appears to increase myofilament calcium sensitivity by binding to cardiac troponin C (Ca+2-dependent) [2]

General

inotropic agent

Database Correlations

PUBCHEM cid=3033825

References

  1. Gordon AC et al. Levosimendan for the prevention of acute organ dysfunction in sepsis. N Engl J Med 2016 Oct 5 PMID: 27705084 Free Article
  2. PubChem: 3033825
  3. Mehta RH, Leimberger JD, van Diepen S et al. Levosimendan in patients with left ventricular dysfunction undergoing cardiac surgery. N Engl J Med 2017 Mar 19 PMID: 28316276 Free Article http://www.nejm.org/doi/10.1056/NEJMoa1616218
  4. Landoni G, Lomivorotov VV, Alvaro G et al. Levosimendan for hemodynamic support after cardiac surgery. N Engl J Med 2017 Mar 21 PMID: 28320259 Free Article http://www.nejm.org/doi/10.1056/NEJMoa1616325