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leukostasis
High WBC counts of > 50,000-100,000/uL cause hyperviscosity syndrome resulting in resistance to blood flow in capillary beds & smaller vessels.
Etiology:
1) acute leukemia
- acute myeloid leukemia
2) chronic leukemia
Management:
- leukopheresis & induction chemotherapy for acute myeloid leukemia with WBC > 50,000/uL
- daunorubicin + cytarabine
- also see specific disorder
References
- Medical Knowledge Self Assessment Program (MKSAP) 19
Board Basics. An Enhancement to MKSAP19.
American College of Physicians, Philadelphia 2022