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leukocytoclastic vasculitis; hypersensitivity vasculitis; trisymptome
Etiology:
1) autoimmune disease
- systemic lupus erythematosus
2) recent viral infection
- hepatitis C, cryoglobulinemia
3) malignancy - lymphoproliferative disorders
4) drug adverse effect
5) systemic vasculitis
6) idiopathic (40%) [1]
Clinical manifestations:
- palpable purpura
- cutaneous vesicles, pustules, maculopapular lesions, urticaria
- occurs within 2 weeks of exposure to offending agent
- generally resolves when the offending agent is removed [1]
Laboratory: skin biopsy
Differential diagnosis:
- exanthematous drug eruption (morbilliform exanthem)
Management:
1) generally self-limited
- withdrawal of offending agent
2) glucocorticoids
3) see acute leukocytoclastic vasculitis (Henoch-Schonlein purpura) or specific etiology
Interactions
disease interactions
Related
cryoglobulinemia (cryoglobulinemic vasculitis)
leukocytoclasis
serum sickness; serum sickness-like reaction
Specific
acute leukocytoclastic vasculitis (Henoch-Schonlein purpura; IgA vasculitis)
chronic leukocytoclastic vasculitis (Gougerot-Ruiter type)
cutaneous leukocytoclastic vasculitis
urticarial vasculitis
General
type 3 hypersensitivity; immune complex hypersensitivity
vasculitis
References
- Medical Knowledge Self Assessment Program (MKSAP) 14, 16, 17, 18, 19.
American College of Physicians, Philadelphia 2006, 2012, 2015, 2018. 2022.
- Eastham ABW, Diamond HS (images)
Medscape: Leukocytoclastic Vasculitis.
http://emedicine.medscape.com/article/333891-overview
- Kroshinsky D
Adverse cutaneous reactions to medications
Clin Dermatol. 2020 Nov-Dec;38(6):605-606
PMID: 33341194