leucine zipper tumor suppressor 1 (F37/esophageal cancer-related gene-coding leucine-zipper motif, Fez1, LZTS1)

Function: 1) role in regulation of cell growth 2) may stabilize active CDC2-cyclin B1 complex 3) role as tumor suppressor (putative) 4) binds EEF1G & CDC2 5) phorphorylated on Ser - hyperphosphorylated by cAMP-dependent kinase PKA during cell-cycle progression Structure: - belongs to the LZTS family Compartment: - cytoplasm, cell membrane - associated with plasma membrane & with microtubules - detected in dendritic spines, especially in the postsynaptic density Alternative splicing: named isoforms=7 Expression: - expressed in testis, prostate, spleen, thymus, ovary, brain > heart, placenta, small intestine, colon, liver, kidney, skeletal muscle, pancreas Pathology: - not detectable in primary tumors from breast & prostate & in many cancer cell lines - defects in LZTS1 are found in many types of tumors

General

anti-oncoprotein (tumor suppressor protein) myristoylated protein phosphoprotein

Properties

SIZE: MW = 66 kD entity length = 595 aa COMPARTMENT: cytoplasm MOTIF: myristoylation site SITE: G1 EFFECTOR-BOUND: myristate coiled coil {255-373}

Database Correlations

OMIM 606551 MORBIDMAP 606551 UniProt Q9Y250 Pfam PF06818

References

UniProt :accession Q9Y250