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leucine-rich glioma-inactivated protein 1 IgG Ab in CSF

Pathology: - may play a role in malignant gliomas - LGI1 Ab in CSF is the most common antibody to neuronal cell surface antigens in elderly with encephalopathy without evidence of CNS inflammation by brain MRI or CSF pleocytosis [2] - 85% present with fasciobrachial dystonic seizures [2] * see LGI1

Related

cerebrospinal fluid leucine-rich glioma-inactivated protein 1 (epitempin-1, LGI1)

General

leucine-rich glioma-inactivated protein 1 IgG Ab in body fluid

References

  1. Loinc
  2. Probasco JC Antibody-Associated CNS Syndromes Without Inflammation in Elders. NEJM Journal Watch. Nov 7, 2017 Massachusetts Medical Society (subscription needed) http://www.jwatch.org - Escudero DEscudero D, Guasp M, Arino H et al. Antibody-associated CNS syndromes without signs of inflammation in the elderly. Neurology 2017 Oct 3; 89:1471 PMID: 28878050