LETM1 domain-containing protein 1 (cervical cancer 1 proto-oncogene protein p40, cervical cancer proto-oncogene 2 protein, HCRR-2, LETMD1)

Function: - role in tumorigenesis & may function as a negative regulator of the TP53/p53 Structure: contains 1 LETM1 domain Compartment: membrane (putative) Alternative splicing: named isoforms=6 Expression: - kidney, liver, skeletal muscle, heart & brain Pathology: - overexpressed in various tumors including leukemia, lymphoma, & carcinomas of the breast, kidney, ovary, stomach, colon & uterine cervix

General

glycoprotein membrane protein

Properties

SIZE: entity length = 360 aa MW = 42 kD COMPARTMENT: cellular membrane MOTIF: LETM1 {75-346} MOTIF: transmembrane domain {138-158} N-glycosylation site {N313}

Database Correlations

UniProt Q6P1Q0 Pfam PF07766

References

UniProt :accession Q6P1Q0