Search
Legionella pneumophila
Etiologic agent of Legionnaire's disease.
Epidemiology:
-> accounts for 85% of Legionella pneumonia Risk factors: (see Legionella)
Genetics:
- stop codon polymorphism in position 352 of TLR5 results in individuals unable to mediate flagellin signaling
- expressed in dominant fashion
Clinical manifestations:
- see Legionnaire's disease
Laboratory:
- Legionella pneumophila serology
- Legionella pneumophila serogroup
- at least 14 serotypes 1-14
- Legionella pneumophila antigen in tissue/body fluid
- Legionella pneumophila antigen in urine
- Legionella pneumophila antigen in sputum
- Legionella pneumophila DNA
- also see Legionnaire's disease
- also see Legionella for other diagnostic laboratory studies
- see ARUP consult [6]
Radiology: (Chest X-ray)
- see Legionnaire's disease
Management: (antimicrobial therapy)
- see Legionnaire's disease
Related
Legionella DNA
Legionella identified by culture
Legionnaire's disease
Toll-like receptor 5; Toll/interleukin-1 receptor-like protein 3 (TLR5, TIL3)
General
Legionella
Properties
KINGDOM: monera
DIVISION: SCHIZOMYCETES
Database Correlations
OMIM 608556
References
- Manual of Medical Therapeutics, 28th edition, Ewald &
McKenzie (eds) Little, Brown & Co, 1995, pg 302
- Harrison's Principles of Internal Medicine, 13th ed.
Companion Handbook, Isselbacher et al (eds), McGraw-Hill
Inc. NY, 1995, pg 228-29
- Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed)
Lippincott-Raven, Philadelphia, 1998, pg 797
- Medical Knowledge Self Assessment Program (MKSAP) 11, American
College of Physicians, Philadelphia 1998
- Journal Watch 25(8):63-64, 2005
Blazquez Garrido RM, Espinosa Parra FJ, Alemany Frances L,
Ramos Guevara RM, Sanchez-Nieto JM, Segovia Hernandez M,
Serrano Martinez JA, Huerta FH.
Antimicrobial chemotherapy for legionnaires disease:
levofloxacin versus macrolides.
Clin Infect Dis. 2005 Mar 15;40(6):800-6. Epub 2005 Feb 17.
PMID: 15736011
- ARUP Consult: Legionella pneumophila
The Physician's Guide to Laboratory Test Selection & Interpretation
https://www.arupconsult.com/content/legionella-pneumophila