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low-density lipoprotein receptor; LDL receptor; apoB/E receptor (LDLR)

Function: - binds LDL, the major cholesterol-carrying lipoprotein of plasma, & transports it into cells by endocytosis - in order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits - the LDL receptor binds 2 ligands, apo B-100 & apo-E, apolipoproteins with completely different sequences - interacts with LDLRAP1 - interacts with SNX17 Structure: - N- & O-glycosylated - belongs to the LDLR family - contains 3 EGF-like domains - contains 7 LDL-receptor class A domains - contains 6 LDL-receptor class B repeats - Ser/Asp/Glu triplet at C-terminal end of L-module is important for ligand-binding Compartment: membrane, clathrin-coated pit Expression: - mRNA for the LDL receptor is expressed in a variety of tissues including liver & adrenals Pathology: - defects in LDLR are the cause of familial hypercholesterolemia) - interacts with HIV-1 Tat in case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells - interacts with HCV E1/E2 heterodimer Note: - also see apo B-48 receptor

Related

apolipoprotein B-48 receptor; apoB48 receptor; apoB-48R (APOB48R, APOBR) CD36; platelet glycoprotein 4; platelet glycoprotein IV; GPIV; glycoprotein IIIb; GPIIIB; leukocyte differentiation antigen CD36; PAS IV; PAS-4; platelet collagen receptor; fatty acid translocase; FAT; Thrombospondin receptor (GP3B, GP4) low density lipoprotein (LDL, beta-lipoprotein) low-density lipoprotein (LDL) receptor related protein (LRP) low-density lipoprotein [LDL] receptor gene

Specific

oxidized low-density lipoprotein receptor 1; Ox-LDL receptor 1; lectin-type oxidized LDL receptor 1; lectin-like oxidized LDL receptor 1; lectin-like oxLDL receptor 1; LOX-1; hLOX-1 (OLR1, LOX1)

General

glycoprotein lipoprotein receptor phosphoprotein

Properties

SIZE: entity length = 860 aa MW = 95 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-21} LDL-receptor class A {25-65} MOTIF: cysteine residue {C27} MODIFICATION: cysteine residue {C39} cysteine residue {C34} MODIFICATION: cysteine residue {C52} cysteine residue {C39} MODIFICATION: cysteine residue {C27} cysteine residue {C46} MODIFICATION: cysteine residue {C63} cysteine residue {C52} MODIFICATION: cysteine residue {C34} cysteine residue {C63} MODIFICATION: cysteine residue {C46} LDL-receptor class A {66-106} MOTIF: cysteine residue {C68} MODIFICATION: cysteine residue {C82} cysteine residue {C75} MODIFICATION: cysteine residue {C95} cysteine residue {C82} MODIFICATION: cysteine residue {C68} cysteine residue {C89} MODIFICATION: cysteine residue {C104} cysteine residue {C95} MODIFICATION: cysteine residue {C75} N-glycosylation site {N97} cysteine residue {C104} MODIFICATION: cysteine residue {C89} LDL-receptor class A {107-145} MOTIF: cysteine residue {C109} MODIFICATION: cysteine residue {C121} cysteine residue {C116} MODIFICATION: cysteine residue {C134} cysteine residue {C121} MODIFICATION: cysteine residue {C109} cysteine residue {C128} MODIFICATION: cysteine residue {C143} cysteine residue {C134} MODIFICATION: cysteine residue {C116} cysteine residue {C143} MODIFICATION: cysteine residue {C128} LDL-receptor class A {146-186} MOTIF: cysteine residue {C148} MODIFICATION: cysteine residue {C160} cysteine residue {C155} MODIFICATION: cysteine residue {C173} N-glycosylation site {N156} cysteine residue {C160} MODIFICATION: cysteine residue {C148} cysteine residue {C167} MODIFICATION: cysteine residue {C184} cysteine residue {C173} MODIFICATION: cysteine residue {C155} cysteine residue {C184} MODIFICATION: cysteine residue {C167} LDL-receptor class A {195-233} MOTIF: cysteine residue {C197} MODIFICATION: cysteine residue {C209} cysteine residue {C204} MODIFICATION: cysteine residue {C222} cysteine residue {C209} MODIFICATION: cysteine residue {C197} cysteine residue {C216} MODIFICATION: cysteine residue {C231} cysteine residue {C222} MODIFICATION: cysteine residue {C204} cysteine residue {C231} MODIFICATION: cysteine residue {C216} LDL-receptor class A {234-272} MOTIF: cysteine residue {C236} MODIFICATION: cysteine residue {C248} cysteine residue {C243} MODIFICATION: cysteine residue {C261} cysteine residue {C248} MODIFICATION: cysteine residue {C236} cysteine residue {C255} MODIFICATION: cysteine residue {C270} cysteine residue {C261} MODIFICATION: cysteine residue {C243} cysteine residue {C270} MODIFICATION: cysteine residue {C255} N-glycosylation site {N272} LDL-receptor class A {274-313} MOTIF: cysteine residue {C276} MODIFICATION: cysteine residue {C289} cysteine residue {C284} MODIFICATION: cysteine residue {C302} cysteine residue {C289} MODIFICATION: cysteine residue {C276} cysteine residue {C296} MODIFICATION: cysteine residue {C313} cysteine residue {C302} MODIFICATION: cysteine residue {C284} cysteine residue {C313} MODIFICATION: cysteine residue {C296} EGF domain {314-353} MOTIF: cysteine residue {C318} MODIFICATION: cysteine residue {C329} cysteine residue {C325} MODIFICATION: cysteine residue {C338} cysteine residue {C329} MODIFICATION: cysteine residue {C318} cysteine residue {C338} MODIFICATION: cysteine residue {C325} cysteine residue {C340} MODIFICATION: cysteine residue {C352} cysteine residue {C352} MODIFICATION: cysteine residue {C340} EGF domain {354-393} MOTIF: cysteine residue {C358} MODIFICATION: cysteine residue {C368} cysteine residue {C364} MODIFICATION: cysteine residue {C377} cysteine residue {C368} MODIFICATION: cysteine residue {C358} cysteine residue {C377} MODIFICATION: cysteine residue {C364} cysteine residue {C379} MODIFICATION: cysteine residue {C392} cysteine residue {C392} MODIFICATION: cysteine residue {C379} LDL-receptor class B {397-438} LDL-receptor class B {439-485} LDL-receptor class B {486-528} MOTIF: N-glycosylation site {N515} LDL-receptor class B {529-572} LDL-receptor class B {573-615} LDL-receptor class B {616-658} MOTIF: N-glycosylation site {N657} EGF domain {663-712} MOTIF: cysteine residue {C667} MODIFICATION: cysteine residue {C681} cysteine residue {C677} MODIFICATION: cysteine residue {C696} cysteine residue {C681} MODIFICATION: cysteine residue {C667} cysteine residue {C696} MODIFICATION: cysteine residue {C677} cysteine residue {C698} MODIFICATION: cysteine residue {C711} cysteine residue {C711} MODIFICATION: cysteine residue {C698} Clustered O-linked oligosaccharides {721-768} transmembrane domain {789-810} Endocytosis signal {823-828} Tyr phosphorylation site {Y845} MISC-INFO: LIGAND = APOLIPOPROTEIN_B100 LIGAND = APOLIPOPROTEIN_E 1/2life 18 HOURS

References

  1. Cantley LC, Auger KR, Carpenter C, Duckworth B, Graziani A, Kapeller R, Soltoff S. Oncogenes and signal transduction. Cell. 1991 Jan 25;64(2):281-302. Review. Erratum in: Cell 1991 May 31;65(5):following 914. PMID: 1846320
  2. Baron M, Norman DG, Campbell ID. Protein modules. Trends Biochem Sci. 1991 Jan;16(1):13-7. Review. PMID: 2053133
  3. Primary Hyperlipoproteinemias, Steiner & Shafrir (eds), McGraw Hill, NY, 1991, pg 31
  4. Yamamoto et al Cell 39:27 1984 (cDNA sequence)
  5. UniProt :accession P01130
  6. LDLR; Note: LDLR mutation database http://www.ucl.ac.uk/fh/
  7. GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=LDLR
  8. SHMPD; The Singapore human mutation and polymorphism database http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=LDLR

Databases & Figures

OMIM correlations MORBIDMAP 606945 UniProt P01130 PFAM correlations Kegg hsa:3949 Figures/diagrams/slides/tables related to low-density lipoprotein receptor