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lactate dehydrogenase B (LDH H subunit, LDHB, LDH heart subunit, LDH-H, renal carcinoma antigen NY-REN-46, LDHB)
Function:
- fermentation; pyruvate fermentation to lactate;
- (S)- lactate from pyruvate: step 1/1
(S)-lactate + NAD+ pyruvate + NADH
Structure:
- homotetramer
- belongs to the LDH/MDH superfamily, LDH family
Compartment: cytoplasm
Pathology:
- defects in LDHB are a cause of hereditary LDHB deficiency
General
phosphoprotein
protein subunit
Properties
SIZE: entity length = 334 aa
MW = 37 kD
COMPARTMENT: cytoplasm
MOTIF: cofactor-binding site [100-100]
COFACTOR-BOUND: NAD
binding site
SITE: 107-107
FOR-BINDING-OF: Substrate
binding site
SITE: 139-139
FOR-BINDING-OF: NAD or substrate
binding site
SITE: 170-170
FOR-BINDING-OF: Substrate
histidine residue {H194}
Tyr phosphorylation site {Y240}
binding site
SITE: 249-249
FOR-BINDING-OF: Substrate
Database Correlations
OMIM 150100
MORBIDMAP 150100
UniProt P07195
PFAM correlations
Entrez Gene 3945
KEGG correlations
ENZYME 1.1.1.27
References
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=LDHB
- Wikipedia, lactate dehydrogenase entry
http://en.wikipedia.org/wiki/lactate_dehydrogenase
- UniProt :accession P07195
Component-of
lactate dehydrogenase 4 (LDH4)