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lactate dehydrogenase (LDH) electrophoresis; lactate dehydrogenase isozymes in serum/plasma
Indications:
- obsolete method of assessing recent myocardial infarction
- largely replaced by troponin I in serum
Clinical significance:
- increase in LD-1 & LD-2 (anodic isozyme pattern)
- hemolysis
- ineffective erythropoiesis
- renal infarction
- germ cell tumors
- myocardial infarction
- muscular dysrophy
- increase in LD-3 (rare) (midzone pattern)
- infectious mononucleosis
- disseminated intravascular coagulation (DIC)
- platelet destruction
- splenic necrosis
- manlignancy
- increase in LD-5 (cathodic isozyme pattern)
- hepatic damage
- most frequently from congestive heart failure in hospitalized patients
- skeletal muscle injury
- prostate carcinoma
- malignancy
Notes:
- LD-5 1/2life: 10 hours
- LD-1 1/2 life: 100 hours
Related
lactate dehydrogenase (LDH) in serum
General
electrophoresis
clinical chemistry test
References
- McKenzie D and Henderson AR
Electrophoresis of Lactate Dehydrogenase Isoenzymes
CLINICALCHEMISTRY,Vol. 29, No. 1, 1983
http://www.clinchem.org/content/29/1/189.full.pdf
Components
lactate dehydrogenase 1 in serum/plasma
lactate dehydrogenase 1/lactate dehydrogenase 2 in serum/plasma
lactate dehydrogenase 1/lactate dehydrogenase total in serum/plasma
lactate dehydrogenase 2 in serum/plasma
lactate dehydrogenase 2/lactate dehydrogenase total in serum/plasma
lactate dehydrogenase 3 in serum/plasma
lactate dehydrogenase 3/lactate dehydrogenase total in serum/plasma
lactate dehydrogenase 4 in serum/plasma
lactate dehydrogenase 4/lactate dehydrogenase total in serum/plasma
lactate dehydrogenase 5 in serum/plasma
lactate dehydrogenase 5/lactate dehydrogenase total in serum/plasma