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lactate dehydrogenase 2 (LDH2)
Structure:
- composed of 3 LDH H subunits & 1 LDH M subunit [1]
Expression:
- expressed in the reticuloendothelial system [1]
Laboratory:
- 40% of serum LDH activity [2]
General
lactate dehydrogenase (LDH)
Properties
SIZE: MW = 134 kD
COMPARTMENT: cytoplasm
CELL: most cell types*
WITHIN: anatomic structure*
in vitro
MOTIF: active site
SUBUNITS: LDH H subunit (3)
MOTIF: cofactor-binding site [100-100]
COFACTOR-BOUND: NAD
binding site
SITE: 107-107
FOR-BINDING-OF: Substrate
binding site
SITE: 139-139
FOR-BINDING-OF: NAD or substrate
binding site
SITE: 170-170
FOR-BINDING-OF: Substrate
histidine residue {H194}
Tyr phosphorylation site {Y240}
binding site
SITE: 249-249
FOR-BINDING-OF: Substrate
LDH M subunit (1)
MOTIF: cofactor-binding site [29-57]
COFACTOR-BOUND: NAD
cofactor-binding site [99-99]
COFACTOR-BOUND: NAD
binding site
SITE: 106-106
FOR-BINDING-OF: Substrate
binding site
SITE: 138-138
FOR-BINDING-OF: NAD or substrate
binding site
SITE: 169-169
FOR-BINDING-OF: Substrate
histidine residue {H193}
Tyr phosphorylation site {Y239}
binding site
SITE: 248-248
FOR-BINDING-OF: Substrate
References
- Wikipedia, lactate dehydrogenase entry
http://en.wikipedia.org/wiki/lactate_dehydrogenase
- Laboratory Medicine: Test Selection & Interpretation.
Howanitz & Howanitz (eds), Churchill Livingstone, NY,
1991, pg 32
Components
lactate dehydrogenase A or LDH M subunit
lactate dehydrogenase B (LDH H subunit, LDHB, LDH heart subunit, LDH-H, renal carcinoma antigen NY-REN-46, LDHB)