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lactate dehydrogenase 5 (LDH5)
Structure:
- composed of 4 LDH M subunits [1]
Expression:
- expressed in liver & skeletal muscle [1]
Laboratory:
- 7% of serum LDH activity [2]
General
lactate dehydrogenase (LDH)
Properties
SIZE: MW = 134 kD
COMPARTMENT: cytoplasm
CELL: most cell types*
WITHIN: anatomic structure*
in vitro
MOTIF: active site
SUBUNITS: LDH M subunit (4)
MOTIF: cofactor-binding site [29-57]
COFACTOR-BOUND: NAD
cofactor-binding site [99-99]
COFACTOR-BOUND: NAD
binding site
SITE: 106-106
FOR-BINDING-OF: Substrate
binding site
SITE: 138-138
FOR-BINDING-OF: NAD or substrate
binding site
SITE: 169-169
FOR-BINDING-OF: Substrate
histidine residue {H193}
Tyr phosphorylation site {Y239}
binding site
SITE: 248-248
FOR-BINDING-OF: Substrate
MISC-INFO: lifetime 8-12 HOURS {1/2-LIFE}
References
- Wikipedia, lactate dehydrogenase entry
http://en.wikipedia.org/wiki/lactate_dehydrogenase
- Laboratory Medicine: Test Selection & Interpretation.
Howanitz & Howanitz (eds), Churchill Livingstone, NY,
1991, pg 32
Components
lactate dehydrogenase A or LDH M subunit