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neutrophil gelatinase-associated lipocalin; NGAL; p25; 25 kD alpha-2-microglobulin-related subunit of MMP-9; lipocalin-2; oncogene 24p3 (LCN2, HNL, NGAL)
Function:
- transport of small lipophilic substances (putative)
- forms a covalently linked, disulfide-bridged heterodimer with the 92 kD type V collagenase (MMP-9)
Structure: belongs to the calycin superfamily, lipocalin family
Compartment: secreted
Expression:
- expressed in bone marrow & in tissues that are prone to exposure to microorganism
- high expression in bone marrow, uterus, prostate, salivary gland, stomach, appendix, colon, trachea & lungs
- not found in small intestine or peripheral blood leukocytes
General
glycoprotein
lipocalin
Properties
SIZE: entity length = 198 aa
MW = 23 kD
MOTIF: signal sequence {1-20}
N-glycosylation site {N85}
cysteine residue {C96}
MODIFICATION: cysteine residue {C195}
cysteine residue {C195}
MODIFICATION: cysteine residue {C96}
Database Correlations
OMIM 600181
UniProt P80188
Pfam PF00061
Entrez Gene 3934
Kegg hsa:3934
References
UniProt :accession P80188