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lobular carcinoma in-situ (LCIS)
breast lobular carcinoma in situ.
Pathology:
- abnormal cells within the lobules of the breast
- considered a marker for increased risk of cancer, not itself an invasive cancer
Laboratory:
- LCIS in breast cancer specimen
- nearly always estrogen receptor positive Complication:
- increased risk for development of
- invasive breast ductal carcinoma
- invasive breast lobular carcinoma
Management:
- tamoxifen for premenopausal women
- tamoxifen or aromatase inhibitor for post-menopausal women
- radiation therapy not indicated
- bilateral mastectomy &/or bilateral salpingo-oophorectomy for patients with BRCA1 mutation or BRCA2 mutation
General
carcinoma in situ
lobular carcinoma, breast
References
- Afonso N, Bouwman D.
Lobular carcinoma in situ.
Eur J Cancer Prev. 2008 Aug;17(4):312-6.
PMID: 18562954 Review.