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late cornified envelope protein 3C; late envelope protein 15; small proline-rich-like epidermal differentiation complex protein 3A (LCE3C, LEP15, SPRL3A)
Function:
- precursors of the cornified envelope of the stratum corneum
Structure: belongs to the LCE family
Expression:
- skin-specific
- expressed in adult trunk skin, adult arm skin, fetal skin, penile skin, vulva, esophagus, tongue
- not expressed in the cervix, rectum, lung, colon, placenta
Pathology:
- deletion of the late cornified envelope LCE3B & LCE3C genes may be susceptibility factors for psoriasis
Genetics:
- gene belongs to the LCE cluster present on 1q21
General
late cornified envelope protein
Properties
SIZE: MW = 10 kD
entity length = 94 aa
MOTIF: proline-rich region
SITE: 12-33
MOTIF: proline residue (SEVERAL)
Database Correlations
OMIM 612615
UniProt Q5T5A8
Pfam PF14672
Entrez Gene 353144
Kegg hsa:353144
References
UniProt :accession Q5T5A8