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late cornified envelope protein 3B; late envelope protein 14 (LCE3B, LEP14)
Function:
- precursors of cornified envelope of stratum corneum
Structure: belongs to the LCE family
Expression:
- skin-specific
- expression in adult trunk skin, adult arm skin, fetal skin, penile skin, vulva, esophagus, tongue
- not expressed in the cervix, rectum, lung, colon, placenta
Pathology:
- deletion of the late cornified envelope LCE3B & LCE3C genes may be susceptibility factors for psoriasis
Genetics:
- gene belongs to the LCE cluster present on 1q21
General
late cornified envelope protein
Properties
SIZE: MW = 10 kD
entity length = 95 aa
MOTIF: cysteine-rich region {3-95}
Database Correlations
OMIM 612614
UniProt Q5TA77
Pfam PF14672
Entrez Gene 353143
Kegg hsa:353143
References
UniProt :accession Q5TA77