serine/threonine protein kinase LATS2; large tumor suppressor homolog 2; serine/threonine protein kinase kpm; kinase phosphorylated during mitosis protein; Warts-like kinase (LATS2, KPM)

Function: - negative regulator of YAP1 in the Hippo signaling pathway - phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus - tumor suppressor involved in: a) centrosome duplication b) maintenance of mitotic fidelity c) genomic stability - negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity - negative regulator of the androgen receptor - autophosphorylated & phosphorylated during M-phase & the G1/S-phase of the cell cycle - phosphorylated & activated by STK3/MST2 - interacts with & is phosphorylated by AURKA. - interacts with JUB during mitosis & this complex regulates organization of the spindle apparatus through recruitment of gamma-tubulin to the centrosome - interacts (via PPxY motif) with YAP1 (via WW domains) - interacts with MOBKL1A & MOBKL1B Cofactor: Mg⁺² Compartment: - co-localizes with STK6 at the centrosomes during interphase, early prophase & cytokinesis - migrates to the spindle poles during mitosis, & to the midbody during cytokinesis Expression: - expressed at high levels in heart & skeletal muscle

Properties

SIZE: MW = 120 kD entity length = 1088 aa STATE: active state MOTIF: Ser phosphorylation site {S83} UBA domain {98-139} kinase domain SITE: 668-973 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 697-697 ATP-binding site NAME: ATP-binding site SITE: 674-782 aspartate residue {D791}

Database Correlations

OMIM 604861 UniProt Q9NRM7 PFAM correlations Entrez Gene 26524 Kegg hsa:26524 ENZYME 2.7.11.1

References

UniProt :accession Q9NRM7