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serine/threonine protein kinase LATS1; large tumor suppressor homolog 1; WARTS protein kinase; h-warts (LATS1, WARTS)
Function:
1) tumor suppressor involved in maintenance of ploidy via
a) mitotic progression
b) G1 tetraploidy checkpoint.
2) negatively regulates G2/M transition; down-regulates CDC2 kinase activity
3) regulates actin polymerization; negative modulation of LIMK1
4) complexes with CDC2 in early mitosis
5) binds phosphorylated ZYX, locazing to the mitotic spindle
Compartment:
- localizes to the centrosomes throughout interphase
- migrates to the mitotic spindle during mitosis
General
serine/threonine kinase
Properties
SIZE: MW = 127 kD
entity length = 1130 aa
STATE: active state
MOTIF: UBA domain {100-141}
Ser phosphorylation site {S244}
kinase domain
SITE: 705-1010
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 711-719
ATP-binding site
NAME: ATP-binding site
SITE: 734-734
aspartate residue {D828}
Database Correlations
OMIM 603473
UniProt O95835
PFAM correlations
ENZYME 2.7.1.37
References
UniProt :accession O95835