Search
laryngopharyngeal reflux (LPR)
Etiology:
- complication of GERD
Clinical manifestations:
1) hoarseness
2) repetitive throat clearing
3) excessive pharyngeal mucous
4) globus
5) voice changes
6) duration > 3 months
Special laboratory:
- laryngoscopy
- 24 hour esophageal pH monitor (ambulatory)
Differential diagnosis:
- GERD
Management:
1) proton pump inhibitor (PPI) of no benefit [1]
2) acid suppression likely to prevent laryngopharyngeal injury with GERD-associated laryngopharyngeal reflux [2]
3) alkaline water (pH >8.0) & a plant-based, Mediterranean diet plus standard reflux precautions no better than PPI [4]
Related
gastroesophageal reflux disease (GERD)
laryngitis
larynx
pharynx
General
laryngeal disease
reflux
References
- Vaezi MF et al,
Treatment of chronic posterior laryngitis with esomeprazole
Laryngoscope 2006;116:254
PMID: 16467715
- Roh JL, Lee YW, Park HT.
Effect of acid, pepsin, and bile acid on the stenotic
progression of traumatized subglottis.
Am J Gastroenterol. 2006 Jun;101(6):1186-92.
PMID: 16771935
- Wo JM et al,
Double-blind, placebo-controlled trial with single-dose
pantoprozole for laryngopharyngeal reflux.
Am J Gastroenterol 2006, 101:1972
PMID: 16968502
- Vaezi MF et al,
Treatment of chronic posterior laryngitis with esomeprazole.
Laryngoscope 2006, 116:254
PMID: 16467715
- Zalvan CH, Hu S, Greenberg B et al
A Comparison of Alkaline Water and Mediterranean Diet vs
Proton Pump Inhibition for Treatment of Laryngopharyngeal
Reflux.
JAMA Otolaryngol Head Neck Surg. Published online Sept 7, 2017
PMID: 28880991
http://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2652893
- Kavitt RT
Dietary Modifications in the Treatment of Laryngopharyngeal
Reflux - WIll "an Apple a Day" Keep the Laryngopharyngeal
Reflux Away?
JAMA Otolaryngol Head Neck Surg. Published online Sept 7, 2017
PMID: 28880985
http://jamanetwork.com/journals/jamaotolaryngology/article-abstract/2652892