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large cell carcinoma, lung
Pathology:
1) large cells
2) grows faster than adenocarcinoma
3) brain metastases (28%)
Clinical manifestations:
1) clubbing
2) hypertrophic pulmonary osteoarthropathy
Laboratory:
1) serum calcium: hypercalcemia (13%)
2) increased secretion of hCG, LH & FSH may occur
- serum chorionic gonadotropin
- serum luteining hormone
- serum follicle-stimulating hormone
Radiology:
- chest X-ray
a) large masses
b) cavitation (20-25%)
Management:
1) surgery
2) response to radiation & chemotherapy is poor
Interactions
disease interactions
Related
hypertrophic pulmonary osteoarthropathy (Bamberger-Marie syndrome)
General
carcinoma of the lung
References
Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed)
Lippincott-Raven, Philadelphia, 1998, pg 768