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receptor-type tyrosine-protein phosphatase F; Leukocyte common antigen related; LAR (PTPRF, LAR)
Function:
- possible cell adhesion receptor
- possesses an intrinsic protein tyrosine phosphatase activity (PTPase)
- the first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one
- interacts with GRIP1 (putative). interacts with PPFIA1, PPFIA2 & PPFIA3
protein tyrosine phosphate + H2O = protein tyrosine + phosphate
Structure:
- belongs to the protein-tyrosine phosphatase family receptor class 2A subfamily
- contains 8 fibronectin F3 modules
- contains 3 Ig-like C2-type domains
- contains 2 tyrosine-protein phosphatase domains
Compartment:
- membrane; single-pass type 1 membrane protein
Alternative splicing: named isoforms=2
General
adhesion receptor
glycoprotein
tyrosine phosphatase, receptor type
Properties
SIZE: entity length = 1907 aa
MW = 213 kD
COMPARTMENT: cellular membrane
STATE: active state
MOTIF: signal sequence {1-29}
immunoglobulin superfamily domain {33-123}
MOTIF: cysteine residue {C54}
MODIFICATION: cysteine residue {C107}
cysteine residue {C107}
MODIFICATION: cysteine residue {C54}
N-glycosylation site {N117}
immunoglobulin superfamily domain {135-224}
MOTIF: cysteine residue {C156}
MODIFICATION: cysteine residue {C207}
cysteine residue {C207}
MODIFICATION: cysteine residue {C156}
immunoglobulin superfamily domain {232-314}
MOTIF: N-glycosylation site {N250}
cysteine residue {C253}
MODIFICATION: cysteine residue {C298}
N-glycosylation site {N295}
cysteine residue {C298}
MODIFICATION: cysteine residue {C253}
fibronectin type III domain or F3 module {319-407}
fibronectin type III domain or F3 module {413-506}
fibronectin type III domain or F3 module {512-602}
fibronectin type III domain or F3 module {606-703}
fibronectin type III domain or F3 module {708-815}
MOTIF: N-glycosylation site {N721}
fibronectin type III domain or F3 module {817-910}
fibronectin type III domain or F3 module {915-1008}
MOTIF: N-glycosylation site {N959}
N-glycosylation site {N966}
fibronectin type III domain or F3 module {1011-1095}
transmembrane domain {1264-1284}
Tyrosine-protein phosphatase 1 {1352-1607}
MOTIF: binding site
SITE: 1516-1516
FOR-BINDING-OF: Substrate
Substrate binding {1548-1554}
cysteine residue {C1548}
binding site
SITE: 1592-1592
FOR-BINDING-OF: Substrate
Tyrosine-protein phosphatase 2 {1639-1898}
MOTIF: cysteine residue {C1839}
Database Correlations
OMIM 179590
UniProt P10586
PFAM correlations
Entrez Gene 5792
Kegg hsa:5792
ENZYME 3.1.3.48
References
UniProt :accession P10586