LAP2 protein; densin-180-like protein; Erbb2-interacting protein; Erbin (ERBB2IP, ERBIN, KIAA1225, LAP2)

Function: - acts as an adapter ERBB2 receptor in epithelia, restricting its presence to the basolateral membrane of epithelial cells - binds unphosphorylated Tyr-1248 of receptor ERBB2, stabilizing unphosphorylated state - interacts with ERBB2, BPAG1 & ITGB4 - may play role in localization of ERBB2 to the basolateral membrane of epithelial cells - also interacts with ARVCF & delta catenin - interacts (via C-terminus) with DST isoform 3 (via N-terminus) Structure: - belongs to the LAP (LRR & PDZ) protein family - contains 17 LRR repeats (leucine-rich repeats) - contains 1 PDZ domain (DHR domain) Compartment: - cell junction, hemidesmosome - in transfected cells, either diffusely distributed over the cytoplasm or concentrated at the basolateral membrane Alternative splicing: named isoforms=7 Expression: - highly expressed in brain, heart, kidney, muscle & stomach, followed by liver, spleen & intestine

Properties

SIZE: MW = 158 kD entity length = 1412 aa MOTIF: leucine-rich repeat (10) SITE: 21-251 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 252-274 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 275-298 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 300-320 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 321-344 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 346-366 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 367-390 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 757-778 MOTIF: leucine residue (SEVERAL) Ser phosphorylation site {S857} PDZ domain NAME: PDZ domain SITE: 1321-1410

Database Correlations

OMIM 606944 UniProt Q96RT1 PFAM correlations Entrez Gene 55914 Kegg hsa:55914

References

UniProt :accession Q96RT1