lysosome-associated membrane glycoprotein 3; lysosomal-associated membrane protein 3; LAMP-3; DC-lysosome-associated membrane glycoprotein; DC LAMP; protein TSC403; CD208 (LAMP3, DCLAMP, TSC403)

Function: - might change the lysosome function after the transfer of peptide-MHC class 2 molecules to the surface of dendritic cells Structure: belongs to the LAMP family Compartment: - lysosome membrane Expression: - expressed in lymphoid organs & dendritic cells - expressed in lung Pathology: - up-regulated in carcinomas including: - esophageal carcinoma - colorectal carcinoma - ureteral carcinoma - gastric carcinoma - breast carcinoma - fallopian tube carcinoma - thyroid carcinoma - parotid carcinoma

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen lysosome-associated membrane glycoprotein (LAMP)

Properties

SIZE: entity length = 416 aa MW = 44 kD COMPARTMENT: lysosome MOTIF: signal sequence {1-27} threonine-rich region {74-215} MOTIF: threonine residue (SEVERAL) N-glycosylation site {N112} N-glycosylation site {N158} N-glycosylation site {N164} N-glycosylation site {N200} N-glycosylation site {N232} N-glycosylation site {N266} N-glycosylation site {N291} transmembrane domain {382-402}

Database Correlations

OMIM 605883 UniProt Q9UQV4 Pfam PF01299 Entrez Gene 27074 Kegg hsa:27074

References

UniProt :accession Q9UQV4