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lactate dehydrogenase A or LDH M subunit
Function:
- fermentation; pyruvate fermentation to lactate
- (S)-lactate from pyruvate: step 1/1
(S)-lactate + NAD+ pyruvate + NADH
Structure:
- homotetramer
- belongs to the LDH/MDH superfamily, LDH family
Compartment: cytoplasm
Alternative splicing: named isoforms=2
Pathology:
- defects in LDHA are a cause of exertional myoglobinuria
General
phosphoprotein
protein subunit
Properties
SIZE: entity length = 332 aa
MW = 37 kD
COMPARTMENT: cytoplasm
MOTIF: cofactor-binding site [29-57]
COFACTOR-BOUND: NAD
cofactor-binding site [99-99]
COFACTOR-BOUND: NAD
binding site
SITE: 106-106
FOR-BINDING-OF: Substrate
binding site
SITE: 138-138
FOR-BINDING-OF: NAD or substrate
binding site
SITE: 169-169
FOR-BINDING-OF: Substrate
histidine residue {H193}
Tyr phosphorylation site {Y239}
binding site
SITE: 248-248
FOR-BINDING-OF: Substrate
Database Correlations
OMIM 150000
UniProt P00338
PFAM correlations
Entrez Gene 3939
KEGG correlations
ENZYME 1.1.1.27
References
- UniProt :accession P00338
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=LDHA
- Wikipedia; Note: lactate dehydrogenase entry
http://en.wikipedia.org/wiki/lactate_dehydrogenase
Component-of
lactate dehydrogenase 5 (LDH5)