linker for activation of T-cells family member 2 (non-T-cell activation linker, linker for activation of B-cells, membrane-associated adapter molecule, Williams-Beuren syndrome chromosome region 15 protein, LAT2, LAB, NTAL, WBS15, WBSCR15, WBSCR5, HSPC046)

Function: 1) role in FCER1-mediated signaling in mast cells (FCER1 = high affinity immunoglobulin epsilon receptor) - role in BCR-mediated signaling in B-cells (BCR = B-cell antigen receptor) - role in FCGR1-mediated signaling in myeloid cells (high affinity immunoglobulin gamma Fc receptor 1) 2) couples activation of these receptors & their associated kinases with distal intracellular events through recruitment of GRB2 3) when phosphorylated, interacts with GRB2 4) may also interact with SOS1, GAB1 & CBL 5) phosphorylated on Tyr following cross-linking of - BCR in B-cells - FCGR1 in myeloid cells - FCER1 in mast cells 6) phosphorylation induces recruitment of GRB2 7) may be polyubiquitinated Compartment: cell membrane, present in lipid rafts Alternative splicing: named isoforms=3 Expression: - highly expressed in spleen, peripheral blood lymphocytes, germinal centers of lymph nodes - also expressed in placenta, lung, pancreas & small intestine - present in B-cells, NK cells & monocytes - absent from T-cells Pathology: - defects in LAT2 may be a cause of certain cardiovascular & musculo-skeletal abnormalities observed in Williams-Beuren syndrome

General

membrane protein phosphoprotein

Properties

SIZE: MW = 27 kD entity length = 243 aa COMPARTMENT: cellular membrane MOTIF: transmembrane domain {6-26} MOTIF: cysteine residue {C25} MODIFICATION: palmitate COMPARTMENT: membrane cysteine residue {C28} MODIFICATION: palmitate COMPARTMENT: membrane Tyr phosphorylation site {Y136} Tyr phosphorylation site {Y193} Tyr phosphorylation site {Y233}

Database Correlations

OMIM correlations UniProt Q9GZY6

References

UniProt :accession Q9GZY6