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dopa decarboxylase 95-OH tryptophan decarboxylase; aromatic L-amino-acid decarboxylase (DDC, AADC)
Function:
- catalyzes decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine L-5-hydroxytryptophan to serotonin L-tryptophan to tryptamine
- catecholamine biosynthesis
Cofactor: pyridoxal phosphate
Structure:
- homodimer
- belongs to the group II decarboxylase family
Pathology:
- defects in DDC are the cause of aromatic-L-amino-acid decarboxylase deficiency
Pharmacology:
- AADC gene therapy investigational treatment of Parkinson's disease
Laboratory:
- L-dopa decarboxylase in plasma
- L-dopa decarboxylase in CSF
Interactions
molecular events
Related
aromatic L-amino acid decarboxylase (AADC); dopa-decarboxylase gene therapy
indole metabolism
General
aromatic amino-acid decarboxylase
Properties
MOTIF: active site
MOTIF: cofactor-binding site
COFACTOR-BOUND: pyridoxal phosphate
BOUND-VIA: lysine residue
lysine residue
Database Correlations
OMIM correlations
UniProt P20711
Pfam PF00282
Kegg hsa:1644
ENZYME 4.1.1.28
References
- Principles of Biochemistry 6th ed., White, Handler,
Smith, Hill, & Lehman (eds.) McGraw-Hill, NY 1978, pg 722
- UniProt :accession P20711
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=DDC
- Wikipedia, Aromatic L-amino-acid decarboxylase entry
http://en.wikipedia.org/wiki/Aromatic-L-amino-acid_decarboxylase