L-asparaginase (L-asparagine amidohydrolase, asparaginase-like protein 1, ASRGL1, ALP, CRASH)

Function: - acts in asparagine catabolism - may be involved in astroglial production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions L-asparagine + H₂O L-aspartate + NH₃ Structure: belongs to the asparaginase 2 family Compartment: cytoplasm. Note=Midpiece of sperm tail Alternative splicing: named isoforms=2 Expression: - expressed in brain, kidney, testis & tissues of the gastrointestinal tract. - present in sperm (at protein level) - induced by 5-alpha-di-hydrotestosterone & progesterone Pathology: - over-expressed in uterine, mammary, prostatic & ovarian carcinoma Pharmacology: - used as an antineoplastic agent (see asparaginase)

Specific

asparaginase (Elspar) pegaspargase (Oncaspar, PEG-L-asparaginase)

Properties

SIZE: entity length = 308 aa MW = 32 kD MOTIF: threonine residue {T168}

Database Correlations

UniProt Q7L266 Pfam PF01112 ENZYME 3.5.1.1

References

UniProt :accession Q7L266