acute lymphoblastic leukemia, L3 (Burkitt type, mature B-cell ALL)

Burkitt type lymphocytic leukemia. Associated with mature B-cell ALL. Epidemiology: - ~1% of cases in children and 9% of cases in adults. Pathology: morphologic classification: - large uniform cells, - moderately abundant, deeply basophilic cytoplasm with prominent vacuoles - regular nuclei, prominent nucleoli 'starry sky' pattern on bone marro biopsy Management: - Distinction of L1, L2 & L3 not relevant to therapy.

Related

chromosomal translocation t8q24.1:14q32 (B-cell leukemia, Burkitt's lymphoma) PCR/in-situ hybridization for acute lymphoblastic leukemia

References

- Jobbour EJ et al Adult acute lymphoblastic leukemia, Mayo Clin Proc 80(11):1517, 2005 PMID: 16295033