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L1CAM-positive extracellular vesicle alpha-synuclein Ag in serum; L1CAM-positive extracellular vesicle alpha-synuclein Ag in serum
Indications:
- biomarker for alpha-synucleinopathy (Parkinson's disease, Lewy body dementia or multiple system atrophy within 12 years)
Reference interval:
- > 27.93 pg/mL associated with alpha-synucleinopathy within 12 years (specificity - 80%) [1]
Methods:
- L1CAM positive extracellular vesicles isolated from 250 uL of serum by immunocapture
Related
alpha-synuclein; non-A beta component of AD amyloid; non-A4 component of amyloid; NACP (SNCA, NACP, PARK1)
General
alpha synuclein Ag in tissue
References
- Yan S, Chang C, Janzen A et al.
Neuronally derived extracellular vesicle alpha-synuclein as a serum biomarker
for individuals at risk of developing Parkinson disease.
JAMA Neurol 2024 Jan 1; 81:59-68.
PMID: 38048087 PMCID: PMC10696516 Free PMC article
https://jamanetwork.com/journals/jamaneurology/fullarticle/2812433