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Kv channel-interacting protein 1; KChIP1; A-type K+ channel modulatory protein 1; K+ channel-interacting protein 1; vesicle APC-binding protein (KCNIP1, KCHIP1)
Function:
1) regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type K+ channels
2) modulates channels density, inactivation kinetics & rate of recovery from inactivation
3) Ca+2-dependent
4) in vitro, modulates Kv4.1 & Kv4.2 currents
5) Kv4.2 trafficking to the cell surface
6) component of heteromultimeric K+ channels
7) interacts with KCND3 & the N- terminal domain of KCND2
8) probably part of a complex consisting of KCNIP1, KCNIP2 isoform 3 & KCND2
9) interacts with Naja atra venom CTX3
Structure:
- self-associates to form homodimers & homotetramers
- belongs to the recoverin family
- contains 4 EF-hand domains
Compartment: cell membrane
Alternative splicing: named isoforms=5
Expression:
- isoform 1 & isoform 2 expressed in brain, kidney
- isoform 1 also expressed in liver, pancreas, skeletal muscle, small intestine, testis
- isoform 2 also expressed in lung, pancreas, leukocytes, prostate, thymus
General
Ca+2 binding protein
membrane protein
Properties
SIZE: MW = 27 kD
entity length = 227 aa
COMPARTMENT: cellular membrane
MOTIF: EF hand
SITE: 38-94
EF hand
SITE: 97-132
EF hand
SITE: 133-168
EF hand
SITE: 181-216
binding site
SITE: 214-227
FOR-BINDING-OF: K+ voltage-gated channel subfamily D member 2
Database Correlations
OMIM 604660
UniProt Q9NZI2
Pfam PF13499
Entrez Gene 30820
Kegg hsa:30820
References
- UniProt :accession Q9NZI2
- PMID: 12829703
- PMID: 17187064
- PMID: 14980207
- PMID: 15184042
- PMID: 15358149
- PMID: 17057713