Search
keratin, type II cuticular Hb3; type II hair keratin Hb3; keratin-83; K83; K2.10 (KRT83 KRTHB3)
Structure:
- type-2 hair keratin
- heterotetramer of 2 type 1 & 2 type 2 keratins
- belongs to the intermediate filament family
Expression:
- synthesis begins in the cortex 10-15 cell layers above the apex of the dermal papilla & ends abruptly in the middle of the cortex
Pathology:
- defects in KRTHB3 are a cause of monilethrix
General
basic hair keratin or type II hair keratin
Properties
CONFIGURATION: oligomer
SIZE: entity length = 493 aa
MW = 54 kD
COMPARTMENT: cytoplasm
MOTIF: Head {1-111}
O-glycosylation site {N-TERMINAL}
rod-like {central-region}
MOTIF: alpha helix
coiled coil
Rod {112-418}
MOTIF: Coil 1A {112-146}
Linker 1 {147-156}
Coil 1B {157-257}
Linker 12 {258-274}
Coil 2 {275-418}
glutamate-rich region {C-TERMINAL}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site (SEVERAL)
MOTIF-SEQUENCE: KSP
Tail {419-493}
Database Correlations
OMIM correlations
MORBIDMAP 602765
UniProt P78385
Pfam PF00038
Entrez Gene 3889
References
- Entrez Gene :accession 3889
- UniProt :accession P78385
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=KRT83