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keratin, type 2 cytoskeletal 6A; cytokeratin-6A; CK 6A; K6a keratin; cytokeratin-6D; CK 6D; allergen hom s 5 (KRT6A, K6A, KRT6D)
Function:
- KRT6 isomers associate with KRT16 &/or KRT17
- interacts with TCHP
Structure:
- type 2 keratin
- heterodimer of a type 1 & a type 2 keratin
- belongs to the intermediate filament family
Expression:
- constitutively expressed in distinct types of epithelia such as those in oral mucosa, esophagus, papillae of tongue & hair follicle outer root sheath
Pathology:
- defects in KRT6A are a cause of pachyonychia congenita-1
- KRT6A causes an allergic reaction in humans; binds to IgE from atopic dermatitis patients; identified as an IgE autoantigen in atopic dermatitis patients with severe skin manifestations
Notes:
- there are at least 6 isoforms of human type 2 keratin-6, K6A being the most abundant representing about 77% of all forms found in epithelia
General
cytokeratin 6 (K6)
Properties
CONFIGURATION: oligomer
SIZE: entity length = 564 aa
MW = 60 kD
COMPARTMENT: cytoplasm
MOTIF: Head {2-162}
acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S60}
Rod {163-472}
MOTIF: Coil 1A {163-198}
Linker 1 {199-217}
Coil 1B {218-309}
Linker 12 {310-333}
Coil 2 {334-472}
glutamine residue {414}
Tail {473-564}
Database Correlations
OMIM correlations
MORBIDMAP 148041
UniProt P02538
Pfam PF00038
Entrez Gene 3853
Kegg hsa:3853
References
- UniProt :accession P02538
- Human intermediate Filament mutation Database
http://www.interfil.org
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=KRT6A
- Entrez Gene :accession 3853