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keratin, type 1 cytoskeletal 17; cytokeratin-17; CK-17; keratin-17; K17; p39.1 (KRT17)
Function:
- may play a role in the formation & maintenance of various skin appendages, specifically in determining shape & orientation of hair
- may be a marker of basal cell differentiation in complex epithelia
- required for the correct growth of hair follicles, in particular for the persistence of the anagen phase
- modulates function of TNF-alpha in the specific context of hair cycling
- regulates protein synthesis & epithelial cell growth through binding to the adapter protein SFN & by stimulating Akt/mTOR pathway
- involved in tissue repair
- KRT17 associates with KRT6 isomers
- interacts with TRADD & SFN
Structure:
- type 1 cytokeratin
- heterodimer of a type 1 & a type 2 keratin
- belongs to the intermediate filament family
Compartment: cytoplasm (putative)
Expression:
- expressed in the outer root sheath & medulla region of hair follicle specifically from eyebrow & beard, digital pulp, nail matrix & nail bed epithelium, mucosal stratified squamous epithelia & in basal cells of oral epithelium, palmoplantar epidermis, sweat glands & mammary glands
- also expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of sebaceous gland & in exocervix (at protein level)
- induced in damaged or stressed epidermis
- induced by the cytokines interferon-gamma (IFN-gamma), tumor necrosis factor alpha (TNF-alpha) & transforming growth factor-alpha (TGF-alpha), & by the NF-kappa B inhibitors Bay 11-7082 & Bay 11-7085
- down-regulated by antineoplastic agent Imatinib
Pathology:
- defects in KRT17 are a cause of:
a) pachyonychia congenita type 2
b) steatocystoma multiplex
- KRT16 & KRT17 are coexpressed only in pathological conditions including:
a) cervical metaplasias & cervical carcinomas
b) psoriasis vulgaris
- may act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells, thus causing their proliferation.
General
cytokeratin, epithelial keratins or soft alpha-keratins
phosphoprotein
Properties
CONFIGURATION: oligomer
SIZE: entity length = 432 aa
MW = 48 kD
COMPARTMENT: cytoplasm
MOTIF: Head {2-83}
MOTIF: Ser phosphorylation site {S12}
Ser phosphorylation site {S13}
Ser phosphorylation site {S32}
Ser phosphorylation site {S39}
Rod {84-392}
MOTIF: Coil 1A {84-120}
epitope S1 {102-116}
Linker 1 {121-138}
Coil 1B {139-230}
epitope S2 {153-167}
Linker 12 {231-250}
Coil 2 {251-392}
Ser phosphorylation site {S319}
epitope S4 {332-346}
Tail {393-432}
Database Correlations
OMIM correlations
MORBIDMAP 148069
UniProt Q04695
Pfam PF00038
Entrez Gene 3872
Kegg hsa:3872
References
- UniProt :accession Q04695
- Human intermediate Filament mutation Database
http://www.interfil.org
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=KRT17
- Wikipedia; Note: keratin-17 entry
http://en.wikipedia.org/wiki/keratin_17
- Entrez Gene :accession 3872