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keratin, type 1 cytoskeletal 16; cytokeratin-16; CK-16; keratin-16; K16 (KRT16, KRT16A)
heterodimer of a type I & a type II keratin. KRT16 associates with KRT6 isomers. interacts with TCHP. interacts with TRADD (putative)
Structure: belongs to the intermediate filament family
Expression: expressed in the hair follicle, nail bed and in mucosal stratified squamous epithelia and, suprabasally, in oral epithelium & palmoplantar epidermis. also found in luminal cells of sweat & mammary gland ducts mass spec: mass=50924.66; method=MALDI; Range=2-473 Source=Pubmed:11840567
Pathology:
- defects in KRT16 are a cause of
a) pachyonychia congenita type 1
b) unilateral palmoplantar verrucous nevus
c) palmoplantar keratoderma non-epidermolytic
- KRT16 & KRT17 are coexpressed only in pathological conditions including:
a) cervical metaplasia & cervical carcinoma
b) psoriasis vulgaris
General
cytokeratin, epithelial keratins or soft alpha-keratins
Properties
CONFIGURATION: oligomer
SIZE: entity length = 473 aa
MW = 51 kD
COMPARTMENT: cytoplasm
MOTIF: Head {2-116}
O-glycosylation site {N-TERMINAL}
rod-like {central-region}
MOTIF: alpha helix
coiled coil
Rod {117-424}
MOTIF: Coil 1A {117-152}
Linker 1 {153-170}
Coil 1B {171-262}
Linker 12 {263-285}
Coil 2 {286-424}
glutamate-rich region {C-TERMINAL}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site (SEVERAL)
MOTIF-SEQUENCE: KSP
Tail {425-473}
Database Correlations
OMIM correlations
MORBIDMAP 148067
UniProt P08779
Pfam PF00038
Entrez Gene 3868
Kegg hsa:3868
References
- UniProt :accession P08779
- Human intermediate Filament mutation Database
http://www.interfil.org
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=KRT16
- Entrez Gene :accession 3868