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myosin light chain kinase smooth musle (MLCK, MYLK, telokin, kinase-related protein, KRP)
Function:
1) smooth muscle contraction via phosphorylation of Ser in the N-terminus of myosin light chains
2) growth of astrocytic processes
3) transmitter release at synapses of sympathetic ganglion neurons
4) fibroblast apoptosis
5) precursor to several splice products: telokin, non-muscle MLCK isozyme & smooth muscle MLCK isozyme
6) responsible for smooth muscle contraction via phosphorylation of specific Ser of myosin light chains
General
myosin light chain kinase (MLCK, MYLK)
Properties
SIZE: gel filtration = 124 kD
COMPARTMENT: cytoplasm
STATE: active state
MOTIF: S/T-phosphate
calmodulin binding site
EFFECTOR-BOUND: calmodulin
consensus repeat {868-1063} (11)
kinase domain
SITE: 1464-1719
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 1470-1478
ATP-binding site
NAME: ATP-binding site
SITE: 1493-1493
aspartate residue {D1585}
calmodulin binding site
SITE: 1711-1774
FOR-BINDING-OF: calmodulin
immunoglobulin superfamily domain {1824-1891}
glutamate residue {1906-1914} (9)
MISC-INFO: DISTRIBUTION
:REGIONAL BROAD
:SUBCELLULAR CYTOSOLIC
SUBSTRATE-SPECIFICITY
:RANGE NARROW
calmodulin binding site
:SITE C-TERMINAL
RECOGNITION-MOTIF
:SEQUENCE XKKRXXRXX[S*]X
:REF " - Kemp BE, Pearson RB.
Protein kinase recognition sequence motifs.
Trends Biochem Sci. 1990 Sep;15(9):342-6. Review.
PMID: 2238044"
Database Correlations
OMIM 600922
UniProt Q15746
ENZYME 2.7.11.18
References
UniProt :accession Q15746