E3 ubiquitin-protein ligase RNF123; Kip1 ubiquitination-promoting complex protein 1; RING finger protein 123 (RNF123, KPC1, FP1477)

Function: 1) catalytic subunit of the KPC complex 2) E3 ubiquitin-protein ligase 3) poly-ubiquitination & proteasome-mediated degradation of CDKN1B during G1 phase of cell cycle 4) ubiquitin conjugation, 3rd step 5) interacts with UBADC1 & CDKN1B via its N-terminal domain 6) ubiquitinated, leading to its degradation 7) deubiquitinated by USP19, stimulating CDKN1B ubiquitin- dependent degradation 8) interacts with UBAC1 & CDKN1B via its N-terminal domain Structure: - contains 1 B30.2/SPRY domain - contains 1 RING-type Zn⁺² finger Compartment: cytoplasm Alternative splicing: named isoforms=2

General

enzyme catalytic subunit ring finger protein E3 ubiquitin ligase; ubiquitin-ligating enzyme E3; N end-recognizing protein

Properties

SIZE: MW = 149 kD entity length = 1314 aa COMPARTMENT: cytoplasm MOTIF: B30.2/SPRY {74-254} active site alanine-rich region {1237-1244} MOTIF: alanine residue (SEVERAL) RING-finger {1254-1292} EFFECTOR-BOUND: Zn+2 FOR-BINDING-OF: DNA motif

Database Correlations

OMIM 614472 UniProt Q5XPI4 Pfam PF00622 Entrez Gene 63891 Kegg hsa:63891

References

UniProt :accession Q5XPI4