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CD161; killer cell lectin-like receptor subfamily B member 1; natural killer cell surface protein P1A; HNKR-P1a; NKR-P1A; C-type lectin domain family 5 member B (KLRB1, CLEC5B, NKRP1A)
Function:
1) inhibits natural killer cell (NK cell) cytotoxicity
- induced by IL12 in NK cells
2) stimulation of acid sphingomyelinase/SMPD1with resulting in elevation of intracellular ceramide
3) stimulation of AKT1/PKB & RPS6KA1/RSK1 kinases
4) enhanced T-cell proliferation induced by anti-CD3
5) lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal & N-acetyllactosamine epitopes
6) binds to CLEC2D/LLT1
7) inhibits interferon-gamma secretion
Structure:
1) homodimer, disulfide-linked
2) N-glycosylated
3) contains sialic acid residues
4) contains 1 C-type lectin domain
Compartment: membrane
Expression:
- expressed in a subset of NK cells predominantly in intestinal epithelium & liver
- expressed in peripheral blood T-cells, preferentially in adult T-cells with a memory antigenic phenotype
- induced by IL12 in NK cells
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
C-type (calcium dependent, carbohydrate-recognition domain) lectin superfamily or C-type lectin domain family
glycoprotein
Properties
SIZE: MW = 25 kD
entity length = 225 aa
COMPARTMENT: plasma membrane
MOTIF: transmembrane domain {46-66}
C-type lectin {101-211}
MOTIF: cysteine residue {C122}
MODIFICATION: cysteine residue {C210}
N-glycosylation site {N157}
cysteine residue {C189}
MODIFICATION: cysteine residue {C202}
cysteine residue {C202}
MODIFICATION: cysteine residue {C189}
cysteine residue {C210}
MODIFICATION: cysteine residue {C122}
Database Correlations
OMIM 602890
UniProt Q12918
Pfam PF00059
Entrez Gene 3820
Kegg hsa:3820
References
- UniProt :accession Q12918
- Functional Glycomics gateway - Glycan binding Note: NKRP1
http://www.functionalglycomics.org/glycomics/GBPServlet?&operationtype=view&cbpId=cbp_hum_Ctlect_248