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klotho peptide
Function:
1) anti-aging circulating hormone (putative)
2) inhibits insulin/IGF1 signaling
3) generated by cleavage of membrane-bound klotho precursor
Expression:
- present in serum & CSF
Pathology:
- CSF Klotho levels are diminished in patients with Alzheimer's dementia relative to normal controls & persons with mild cognitive impairment [2]
- diminished CSF Klotho levels are are associated with increased CSF beta-amyloid & CSF p-tau [2]
Comparative biology:
- a single injection of low-dose klotho enhances memory in aged nonhuman primates
- high-dose klotho does not enhance memory [3]
Related
klotho precursor (KL)
General
secreted peptide
Properties
COMPARTMENT: extracellular compartment
References
- UniProt :accession Q9UEF7
- Grontvedt GR, Sando SB, Lauridsen C et al
Association of Klotho Protein Levels and KL-VS Heterozygosity With
Alzheimer Disease and Amyloid and Tau Burden.
JAMA Netw Open. 2022;5(11):e2243232.
- Tozer L.
Anti-ageing protein injection boosts monkeys's memories.
First primate studies to show cognitive benefits of the protein klotho could be a
step towards clinical applications.
Nature News. 2023. July 4.
https://www.nature.com/articles/d41586-023-02214-3
- Castner SA, Gupta S, Wag D et al
Longevity factor klotho enhances cognition in aged nonhuman primates.
Nature Aging. 2023, July 3.
PMID: 37400721
https://www.nature.com/articles/s43587-023-00441-x