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Krueppel-like factor 6; B-cell-derived protein 1; core promoter element-binding protein; GC-rich sites-binding factor GBF; proto-oncogene BCD1; suppressor of tumorigenicity 12 protein; transcription factor Zf9 (KLF6, BCD1, COPEB, CPBP, ST12)
Function:
- transcriptional activator (putative)
- binds a GC box motif
- could play a role in B-cell growth & development
Structure:
- the acidic N-terminal part may favor interaction with the basic domain of transcription factors
- belongs to the krueppel C2H2-type Zn+2-finger protein family
- contains 3 C2H2-type Zn+2 fingers
Compartment: nucleus
Alternative splicing: named isoforms=2
Expression:
- expressed in placenta > spleen, thymus, prostate, testis, small intestine, colon > pancreas, lung, liver, heart, skeletal muscle
- also expressed in fetal brain, spleen & thymus
Pathology:
- defects in KLF6 are a cause of
a) gastric cancer
b) prostate cancer
General
Krueppel-like factor
proto oncogene protein
Properties
SIZE: entity length = 283 aa
MW = 32 kD
COMPARTMENT: cell nucleus
MOTIF: Zn finger C2H2-type
SITE: 200-224
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 230-254
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 260-282
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM correlations
MORBIDMAP 602053
UniProt Q99612
Entrez Gene 1316
Kegg hsa:1316
References
- UniProt :accession Q99612
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/KLF6ID44002ch10p15.html