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Krueppel-like factor 4; epithelial zinc finger protein EZF; Gut-enriched krueppel-like factor (KLF4 EZF GKLF)

Function: - transcription factor - can act both as activator & as repressor - binds the 5'-CACCC-3' core sequence - binds to the promoter region of its own gene & can activate its own transcription - regulates expression of key transcription factors during embryonic development - role in maintaining embryonic stem cells, & in preventing their differentiation - required for establishing the barrier function of the skin & for postnatal maturation & maintenance of the ocular surface - role in differentiation of epithelial cells - may also function in skeletal & kidney development - contributes to down-regulation of p53/TP53 transcription - interacts with POU5F1/OCT4 & SOX2 (putative) - interacts with MUC1 (via the C-terminal domain) Structure: - the 9aaTAD motif is a transactivation domain present in a large number of yeast & animal transcription factors - belongs to the krueppel C2H2-type Zn+2-finger protein family - contains 3 C2H2-type Zn+2 fingers Compartment: nucleus Alternative splicing: named isoforms=3 Notes: - KLF4 is one of the four Yamanaka factors

Related

Yamanaka factor

General

Krueppel-like factor

Properties

SIZE: entity length = 513 aa MW = 55 kD COMPARTMENT: cell nucleus MOTIF: 9aaTAD {101-109} serine-rich region {125-149} MOTIF: serine residue (SEVERAL) proline-rich region SITE: 179-415 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S254} Zn finger C2H2-type SITE: 430-454 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 460-484 EFFECTOR-BOUND: Zn+2 target DNA interaction {473-504} Zn finger C2H2-type SITE: 490-512 EFFECTOR-BOUND: Zn+2

Database Correlations

OMIM 602253 UniProt O43474 Entrez Gene 9314 Kegg hsa:9314

References

  1. UniProt :accession O43474
  2. Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/KLF4ID44316ch9q31.html
  3. SeattleSNPs http://pga.gs.washington.edu/data/klf4/